Radiation therapy for non-aids associated (classic and endemic African) and epidemic Kaposi's sarcoma
Identifieur interne : 006575 ( Main/Exploration ); précédent : 006574; suivant : 006576Radiation therapy for non-aids associated (classic and endemic African) and epidemic Kaposi's sarcoma
Auteurs : Moshe E. Stein [Afrique du Sud] ; Roy Lakier [Afrique du Sud] ; David Spencer [Afrique du Sud] ; Janet Dale [Israël] ; Abraham Kuten [Israël] ; Patrick Macphail [Afrique du Sud] ; Werner R. Bezwoda [Afrique du Sud]Source :
- International Journal of Radiation Oncology, Biology, Physics [ 0360-3016 ] ; 1994.
English descriptors
- Teeft :
- African kaposi, Aids patients, Biol, Classical kaposi, Clin, Complete remission, Complete responders, Daily fractions, Electron beams, Endemic, Endemic african, Epidemic kaposi, Field radiotherapy, Field sizes, Fractionation schedules, Initial treatment modality, Kaposi, Lesion, Local control rate, Local field radiotherapy, Local infection, Lower extremities, Lower limbs, Main complaints, Medical oncology, Modality, Mucositis, Oncol, Oncology, Opportunistic infections, Oral cavity, Phys, Prognostic significance, Protein malnutrition, Radiat, Radiation oncology, Radiation therapy, Radiation therapy oncology group, Radiotherapy, Remission, Retrospective analysis, Rtog dermatitis, Sarcoma, Sars coma, Severe mucositis, Severe skin reactions, Single doses, Skin electron beam irradiation, Skin lesions, Symptomatic relief rates, Total dose, Toxicity.
Abstract
Abstract: Purpose: A retrospective analysis of patients with non-AIDS and AIDS-related Kaposi's sarcoma, who were treated with radiation therapy.Methods and Materials: Between 1978 and 1992, 56 patients with one of the three major types (classical, endemic, epidemic) of Kaposi's sarcoma received radiation therapy as their sole treatment modality. Extent of fields, daily fractionation, and total dose were applied on a clinical basis. These lesions received superficial x-ray therapy, Co-60 teletherapy, or 6–8 MeV electron beams. Field sizes depended on extent of the lesion. Total dose administration ranged from 8–12 Gy in one exposure, or a total of 24–30 Gy fractionated over 2–3 weeks.Results: The majority of patients responded to radiation therapy. Symptomatic relief was achieved in 80–100% of patients irrespective of the type of Kaposi's sarcoma, treatment modality, or schedule. Side effects were tolerable in all but three patients with epidemic type Kaposi's sarcoma, who developed severe mucositis.Conclusion: Radiotherapy is the most useful mode of palliative treatment for all forms of Kaposi's sarcoma in southern African patients.
Url:
DOI: 10.1016/0360-3016(94)90186-4
Affiliations:
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Bezwoda</name><affiliation wicri:level="1"><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Department of Medical Oncology and Hematology, University of the Witwatersrand and Faculty of Medicine, Johannesburg General Hospital, Johannesburg</wicri:regionArea><wicri:noRegion>Johannesburg</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">International Journal of Radiation Oncology, Biology, Physics</title><title level="j" type="abbrev">ROB</title><idno type="ISSN">0360-3016</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1994">1994</date><biblScope unit="volume">28</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="613">613</biblScope><biblScope unit="page" to="619">619</biblScope></imprint><idno type="ISSN">0360-3016</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0360-3016</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>African kaposi</term><term>Aids patients</term><term>Biol</term><term>Classical kaposi</term><term>Clin</term><term>Complete remission</term><term>Complete responders</term><term>Daily fractions</term><term>Electron beams</term><term>Endemic</term><term>Endemic african</term><term>Epidemic kaposi</term><term>Field radiotherapy</term><term>Field sizes</term><term>Fractionation schedules</term><term>Initial treatment modality</term><term>Kaposi</term><term>Lesion</term><term>Local control rate</term><term>Local field radiotherapy</term><term>Local infection</term><term>Lower extremities</term><term>Lower limbs</term><term>Main complaints</term><term>Medical oncology</term><term>Modality</term><term>Mucositis</term><term>Oncol</term><term>Oncology</term><term>Opportunistic infections</term><term>Oral cavity</term><term>Phys</term><term>Prognostic significance</term><term>Protein malnutrition</term><term>Radiat</term><term>Radiation oncology</term><term>Radiation therapy</term><term>Radiation therapy oncology group</term><term>Radiotherapy</term><term>Remission</term><term>Retrospective analysis</term><term>Rtog dermatitis</term><term>Sarcoma</term><term>Sars coma</term><term>Severe mucositis</term><term>Severe skin reactions</term><term>Single doses</term><term>Skin electron beam irradiation</term><term>Skin lesions</term><term>Symptomatic relief rates</term><term>Total dose</term><term>Toxicity</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Purpose: A retrospective analysis of patients with non-AIDS and AIDS-related Kaposi's sarcoma, who were treated with radiation therapy.Methods and Materials: Between 1978 and 1992, 56 patients with one of the three major types (classical, endemic, epidemic) of Kaposi's sarcoma received radiation therapy as their sole treatment modality. Extent of fields, daily fractionation, and total dose were applied on a clinical basis. These lesions received superficial x-ray therapy, Co-60 teletherapy, or 6–8 MeV electron beams. Field sizes depended on extent of the lesion. Total dose administration ranged from 8–12 Gy in one exposure, or a total of 24–30 Gy fractionated over 2–3 weeks.Results: The majority of patients responded to radiation therapy. Symptomatic relief was achieved in 80–100% of patients irrespective of the type of Kaposi's sarcoma, treatment modality, or schedule. Side effects were tolerable in all but three patients with epidemic type Kaposi's sarcoma, who developed severe mucositis.Conclusion: Radiotherapy is the most useful mode of palliative treatment for all forms of Kaposi's sarcoma in southern African patients.</div></front></TEI><affiliations><list><country><li>Afrique du Sud</li><li>Israël</li></country></list><tree><country name="Afrique du Sud"><noRegion><name sortKey="Stein, Moshe E" sort="Stein, Moshe E" uniqKey="Stein M" first="Moshe E." last="Stein">Moshe E. Stein</name></noRegion><name sortKey="Bezwoda, Werner R" sort="Bezwoda, Werner R" uniqKey="Bezwoda W" first="Werner R." last="Bezwoda">Werner R. Bezwoda</name><name sortKey="Lakier, Roy" sort="Lakier, Roy" uniqKey="Lakier R" first="Roy" last="Lakier">Roy Lakier</name><name sortKey="Macphail, Patrick" sort="Macphail, Patrick" uniqKey="Macphail P" first="Patrick" last="Macphail">Patrick Macphail</name><name sortKey="Spencer, David" sort="Spencer, David" uniqKey="Spencer D" first="David" last="Spencer">David Spencer</name></country><country name="Israël"><noRegion><name sortKey="Dale, Janet" sort="Dale, Janet" uniqKey="Dale J" first="Janet" last="Dale">Janet Dale</name></noRegion><name sortKey="Kuten, Abraham" sort="Kuten, Abraham" uniqKey="Kuten A" first="Abraham" last="Kuten">Abraham Kuten</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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